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NLT Adenosphere

1. PRODUCTS & GENERAL INFORMATION

1.1 NanoSphere

GENERAL DESCRIPTION
BioSpectrum's innovative and unique technology provides effective delivery of selected locally acting therapies through topical application. BioSpectrum's delivery system is significantly more effective than other local methods, superior to traditional cosmetic delivery, in terms of delivering a greater quantity of the active ingredients to the site of action, and of reducing systemic side effects.

NANO LIPO TECH (NLT)
Liposomes are microscopic spheres that spontaneously form when certain lipids are suspended in water under the appropriate conditions. The membranes that enclose these spheres resemble (in appearance and function) the biological membranes that enclose cells and constitute their boundary or fill in inter cellular space in the skin. The outermost layer of the skin is composed of lipid bilayers that act as the barrier system. Liposomes also consist of lipid bilayers that are similar in composition to those found in the skin. Liposomes are very compatible with skin. Nano sized liposomes can penetrate through all thickness of skin layers featuring excellent moisturizing and biochemical effects.
Our company produces a wide range of liposomal ingredients of 'NLT NanoSphere' series. NanoSphere's diameter ranges within 100 - 300 nm (proved by electron microscopy and size analyzer studies).

APPLICATION
The use of liposome ingredients 'NanoSphere' in cosmetics allows manufacturing highly effective and very comfortable in use high quality functional skincare and cosmetic products that place them among an elite group of cosmetics. These cosmetics have a number of advantages as follows:

▶ Easy penetrate and soak into the skin
▶ Able to deliver biologically active substances directly into deep skin
▶ Deliver moisturizing substances directly into the skin
▶ Able to reduce an irritant action of some components of cosmetics, e.g. retinol
▶ Biodegradable and non-toxic
▶ Carry both water and oil soluble payloads

1.2 Adenosine

Adenosine is a naturally occurring nucleoside found in many cells of the body. Adenosine receptors, as other G protein-linked receptors, contain seven transmembrane domains, with an intracellular carboxy terminus and an extracellular amino terminus.
There were identified 4 types of adenosine receptors in mammals. A1 and A3 receptors interact with G proteins Gi and A2a and A2b with Gs. They are typically coupled to the adenylate cyclase-cAMP signal-transduction pathway. A1 and A3 also signal via phospolipase C (PLC) and Ca2+.

Adenosine exerts several of its actions by binding to adenosine receptors located on the surface of vascular and skeletal muscle cells
and it is thus in the interstitium that adenosine exerts its action. Adenosine reduces the effect of calcium, the main messenger of contraction, on the inside of the cell. Adenosine drains the skin, leaving it light and smooth. It improves an appearance of wrinkles and increases skin smoothness.

1.3 Function

Facial skin is constantly in motion, as it naturally contracts when frowning, laughing, or blinking, causing skin folds to appear. This process is known as myo-aging, or skin aging caused by facial movements. Muscle tension in the face influences the formation of wrinkles. It is caused by mechanical forces related to repetitive contractions of underlying muscles attached to the dermis. Telltale signs: Facial expression and contraction wrinkles around the eyes ("crow's feet"), on the forehead, and around the lips (creases). The skin is congested, becomes heavy and forms creases. To erase these wrinkles, the skin must be drained to decontract the fibres so that they can regain their natural extension and thus smooth out the skin. NLT AdenoSphere 2.0™ targets the cause of the problem by promoting decontraction of the skin

2. EFFICACY STUDY

Effects of NLT AdenoSphere 2.0 on DNA synthesis. Treatment of porcine coronary artery endothelial cells with adenosine enhanced DNA synthesis. The lowest concentration of NLT AdenoSphere 2.0 that significantly induced cell growth is 0.2%: at a concentration of 2% NLT AdenoSphere 2.0 induced cell growth by approximately 55%. A maximal mitogenic response of 60% increase in cell proliferation was observed in response to 10 % after 4 days of treatment.

Effects of NLT AdenoSphere 2.0 on cell proliferation. Treatment of porcine coronary artery endothelial cells with adenosine enhanced and collagen synthesis. The lowest concentration of NLT AdenoSphere 2.0 that significantly induced cell growth is 0.2%: at a concentration of 2%, NLT AdenoSphere 2.0 induced cell growth by approximately 62%. A maximal mitogenic response of 69% increase in cell proliferation was observed in response to 10 % after 4 days of treatment.

Effects of NLT AdenoSphere 2.0 on collagen synthesis. Treatment of porcine coronary artery endothelial cells with adenosine enhanced and collagen synthesis. The lowest concentration of NLT AdenoSphere 2.0 that significantly induced cell growth is 0.2%: at a concentration of 2%, NLT AdenoSphere 2.0 induced cell growth by approximately 58%. A maximal mitogenic response of 63% increase in cell proliferation was observed in response to 10 % after 4 days of treatment.

3. AREAS OF COMMERACIAL VALUE
▶ As an anti-ageing agent for wrinkle :

● Cosmeceuticals for wrinkle, dry skin, adult acne, and Rosacea and so on.
● Skin products including soaps, cleansers, lotion, gel, cream, and so on for persons with ageing skin.

4. Safety
Safety tests performed on the product have proved the product to be safe for cosmetic use. Listed in CTFA

5. Processing and Dosage
NLT AdenoSphere 2.0 can be processed under 55℃ and is incorporated into the phase after emulsification of a cosmetic formulation. For skin care preparations, we recommend the addition of 2%.

6. Storage and Shelf Life

Room temperature or below, dry condition, sealed under original package. Two years after manufacturing date.

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