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 In
dry, scaly skin, desquamation does not occur properly,
resulting in the formation of visible scales. HumiD-Max™
assists the process of desquamation of the outer layer
of stratum corneum and reduces scaling. Significantly
greater reductions in both degrees of scaling and corneocyte
counts were seen in subjects treated with the formula
containing HumiD-Max™
Fig. 3. Histogram shows reduction in both degree of
Scaling and Corneocyte treated with HumiD-Max™
¢º 2.2 Hydration
Lasting
HumiD-Max™ and a control product were applied on
the forearms of volunteer's twice/day for 7 consecutive
days. One area remained untreated. The skin hydration
was measured before application, and during the application
period at 1, 3 and 7 days. After the application was
ceased (day 7), the measurements were continued on day
8, 10 and 13. The water retention capacity of the skin
was determined by measuring skin hydration using a corneometer
(Courage-Khazaka Electronic GmbH, Germany).
 Result
After the application was ceased, areas treated with
the Control showed a rapid decrease in hydration. In
contrast, HumiD-Max ™ showed a significantly longer
lasting hydration, up to 6 days after the last application
(day 13) of 2 % HumiD-Max .
¢º 2.3 TEWL
Lowering
HumiD-Max™ and a control product
were applied on the forearms of volunteer's twice/day
for 7 consecutive days. One area remained untreated.
Skin hydration was evaluated before application  (baseline)
and two hours after the last application (day 7). The
test areas were then exposed to a 0.5 % aqueous solution
of Sodium Dodecyl Sulphate (SDS) for 12 hours to induce
skin irritation. TEWL was determined using the TEWAmetry
MPA9 (Courage-Khazaka Electronic GmbH, Germany)
Result
After irritation with SDS, untreated skin and areas
treated with the Control showed a large increase in
TEWL. The areas treated with HumiD-Max™ showed
a lower increase in TEWL after SDS irritation, demonstrating
the protective effect of HumiD-Max on the skin.
¢º 2.4 Erythema
Decreasing
HumiD-Max™ and a control product
were applied on the forearms of volunteer's twice/day
for 7 consecutive days. One area remained untreated.
The test areas were then exposed to a 0.5 % aqueous
solution of Sodium Dodecyl Sulphate (SDS) for 12 hours
to induce skin irritation. Erythema was determined using
the Chroma meter (Minolta, Japan)
Result
HumiD-Max™ and a control product were applied on
the forearms of volunteers twice/day for 7 consecutive
days and then exposed to a 0.5 % aqueous solution of
Sodium Dodecyl Sulphate (SDS) for 12 hours to induce
skin irritation The areas treated with HumiD-Max decrease
erythema index irritated with SDS.
3. PRACTICAL HINTS
¢º 3.1 Recommended
Use Level
We are confident in recommending HumiD-Max¢â as an effective
moisturizer for a wide range of product types, from
skin care to shampoos and from creams to gels etc.
Usage levels may vary from 1% to 3%, depending on the
formulation, the typical usage level averages around
2%.
¢º 3.2 How to Get the Most of HumiD-Max¢â
Do not add HumiD-Max¢â to the formulation at temperature
above 55 C, where there is a heating stage. It is recommended
to add after the cooling process.
If possible avoid UV or strong light.
¢º 4. Safety
Safety tests performed on the product have proved the
product to be safe for cosmetic use. Listed in CTFA
¢º 5. Storage and Shelf Life
Room temperature or below, dry condition, sealed under
original package. Two years after manufacturing date.
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