Functional Actives


- Anti-wrinkle


Aging of the skin is directly related to reductions in the levels of Type I collagen (the principal component of the dermal layer of the skin) and regeneration ability of dermal fibroblasts. This causes a rhytide or a fold in the skin also known as a wrinkle. Wrinkles appear on the skin due to influences of intrinsic, extrinsic and mechanical factors. Intrinsic factors are chronological factors such as reduction of new skin cells and pigment containing cells, loss of fat, shrinking bones, and slowing down of collagen. Extrinsic factors are environmental factors like chemicals, pollution, smoking, sunlight and harsh weather conditions. Lastly, mechanical factors are physical movements such as repetitive facial expressions, gravity, and sleeping positions.

Mechanism of wrinkle formation

Wrinkles appear on the skin due to loss of elasticity and are usually caused by rapid degradation of collagen. Wrinkles are generated by the influences of intrinsic, extrinsic and mechanical factors on mitogenic response and signal transduction pathways. receptors such as epidermal growth factor (EGF), interleukin-1 (IL-1r), tumor necrosis factor (TNF-α), platelet-derived growth factor (PDGF), and platelet-activating factor (PAF) on activation stimulate tyrosine kinase and the associated adapter proteins, which transfer the signal to the transcription factor activation protein 1 (AP-1) and initiate the production of matrix metalloproteinases (MMPs). This results in loss of collagen in the skin by disturbing the natural balance between MMPs and MMP inhibitors. AP-1 transcription factor is composed of two subunits: c-fos and c-jun. c-fos is continuously expressed so that the AP-1 activity is limited by c-jun expression in human skin. Interestingly, c-fos expression is known to be similar in young and aged skins, whereas c-jun expression is elevated in aged skin compared to young skin. All these factors induce the collagen metabolism, resulting in reduction of procollagen type I and VII synthesis, disorganization and destruction of collagen, inactivation of tissue inhibitors of metalloproteinases (TIMPS), and induction of MMPs synthesis.



Publications

·Effects of Vegetable Peptones on Promotion of Cell Proliferation and Collagen Production. Journal of the Society of Cosmetic Scientists of Korea, 2009, 35(1), 65-72.


·Asiaticoside Induces Human Collagen I synthesis through TGF β Receptor I Kinase (T β RI Kinase)- Independent Smad Signaling. Planta Medica, 2006, 72, 324-328.


·Panax ginseng induces human Type I collagen synthesis through activation of Smad signaling. Journal of Ethnopharmacology, 2007, 109, 29-34.



Patents

·Registration No.: 10-0901661-0000; Registration Date: 02 Jun, 2009


·Registration No.: 10-0893162-0000; Registration Date: 06 April, 2009.


·Registration No.: 10-0873946-0000; Registration Date: 08 Dec, 2008.


·Registration No.: 10-0862957-0000; Registration Date: 06 Oct, 2008.



Our products

·BsPep-5, Cytopep-4, Dongbaek oil, NLT Adenosphere 2.0, NLT Puesphere 1.0.