The skin is the largest organ of the human body. It has several layers including an outer layer (epidermis), an inner layer with blood vessels, nerves, hair follicles and glands (dermis), and a deeper fatty layer. The skin acts as an interface between the external environment and internal environment of an organism. It has a vital role in maintenance of body temperature, defense against pathogens and irritants, prevention of excess water loss and defense against antioxidant, physical and UV damage.

Inflammation is part of the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, allergens or irritants. The classical signs of acute inflammation are pain, heat, redness, swelling, and loss of function. Inflammation is a protective attempt by the organism to remove the injurious stimuli and to initiate the healing process. Inflammatory abnormalities are a large group of disorders which underlie a vast variety of human diseases. The immune system is often involved with inflammatory disorders, demonstrated in both allergic reactions and skin irritation, with many immune system disorders resulting in abnormal inflammation.

Skin inflammation is caused due to various reasons and some of them are excessive sweating, lack of skin maintenance, sensitivity of the skin, dry skin etc. People with sensitive skin easily develops acne, pimples and rashes than normal skin types when it comes in contact to dust, dirt, allergen and various stimulators. These causes lead to irritation, itching and rashes. Skin irritation is a general term that can refer to a number of skin problems, including lesions, redness and itchiness. Rashes, a specific type of skin irritation, describe any area of skin that is red, itchy and inflamed.

Choosing a gentle, as well as a soothing moisturizer is necessary when it comes to calming down the skin rashes in sensitive and inflamed skin. Cosmetics can be used to help irritated and inflamed skin common with rosacea, atopic dermatitis and acne. These can be taken as a topical cream or lotion. Proper skin care lays the foundation for successful treatment for inflamed skin.

·Evaluation of the anti-inflammatory and atopic dermatitis-mitigating effects of BSASM, a multicompound preparation.Journal of ethnopharmacology. Jan 2005. 96: 211-219

·In vitro antibacterial and anti-inflammatory effects of honokiol and magnolol against Propionibacterium sp.European Journal of Pharmacol. Aug 2004. 2;496(1-3): 189-95

·A composition comprising compounds of natural origin for damaged skin
Korean application No.: KR10-2006-0128500/Filing Date 15 Dec, 2006
(Registration No.: 10-0812596-0000; Registration Date:05. Mar. 2008)
(Registration No.: 10-0812596-0000; Registration Date:05. Mar. 2008)

·Naturotics
Korean application No.: KR10-2006-0031609/Filing Date 04 Apr. 2006
(Registration No.: 10-0812596-0000; Registration Date:05. Mar. 2008)

·MultiExBSASM, HerbEx Centella